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The MTA score is a visual score performed on MRI of the brain using coronal T1 weighted images in a plane parallel to the brainstem axis and through the hippocampus at the level of the anterior pons 5. The score is also validated for assessment on CT brain 6.
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A general problem with the MTA score is the inconsist-ently dened cuto value. Various cutos for pathological MTA scores can be found in the literature, diering by age groups and education level. For example, Velickaite and colleagues [8] elaborated that "at age 75, gender and edu-cation are confounders for MTA grading. A score of ≥ 2 is
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MTA score: 0: no CSF is visible around the hippocampus (normal); 1: choroid fissure is slightly widened; 2: moderate widening of the choroid fissure, mild enlargement of the temporal horn and mild loss of hippocampal height; 3: marked widening of the choroid fissure, moderate enlargement of the temporal horn, and moderate loss of hippocampal hei.
The medial temporal atrophy (MTA) visual rating scale. (ad) Coronal... Download Scientific
Usage An ERICA score of 2 or 3 (see below) has been shown to have higher diagnostic accuracy for distinguishing healthy controls with subjective cognitive decline from individuals with Alzheimer disease than the older medial temporal lobe atrophy (MTA) score 1 . diagnostic accuracy = 91% sensitivity = 83% specificity = 98% Imaging
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Objective To evaluate the diagnostic performance and reliability of the medial temporal lobe atrophy (MTA) scale in patients with Alzheimer's disease. Methods A systematic literature search of MEDLINE and EMBASE databases was performed to select studies that evaluated the diagnostic performance or reliability of MTA scale, published up to January 21, 2021. Pooled estimates of sensitivity and.
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The MTA-score (Scheltens) should be rated on coronal T1-weighted images. on a slice through the corpus of the hippocampus (level of the anterior pons). The scale is based on a visual score of the width of the choroid fissure, the width of the temporal horn, and the height of the hippocampal formation. < 75 years: score 2 or more is abnormal.
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Objective To provide age-specific medial temporal lobe atrophy (MTA) cut-off scores for routine clinical practice as marker for Alzheimer's disease (AD). Methods Patients with AD (n = 832, mean age 81.8 years) were compared with patients with subjective cognitive impairment (n = 333, mean age 71.8 years) in a large single-centre memory clinic. Mean of right and left MTA scores was determined.
Medial temporal atrophy (MTA) scoring illustrated on T1weighted MRI.... Download Scientific
Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer's disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. MTA was rated in 752 MRI examinations, of which 105 were performed in cognitively healthy participants (CH.
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Scores of MTA correlated to age and Mini-mental state examination score. When used to detect DAT from NC, the MTA showed highest diagnostic value than other scales, and when the cutoff score of 1.5 of MTA scale, it obtained an optimal sensitivity (84.5%) and specificity (79.1%) respectively, with a 15.5% of false negative rate.
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Abstract. Background: Medial temporal lobe atrophy (MTA) is a sensitive radiologic marker for Alzheimer disease (AD) and associated with cognitive impairment. The value of MTA in the oldest old (>85 years old) is largely unknown.
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The MTA score, published by Scheltens and colleagues in 1992 [ 4 ], is a simple measure by which mesiotemporal atrophy can be quantified. Using the width of the choroidal fissure, temporal horn, and height of the hippocampal formation, atrophy is evaluated in five grades (0-4).
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To assess inter-modality agreement and accuracy for medial temporal lobe atrophy (MTA) ratings across radiologists with varying clinical experience in a non-demented population. Methods Four raters (two junior radiologists and two senior neuroradiologists) rated MTA on CT and MRI scans using Scheltens' MTA scale.
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Medial temporal lobe atrophy (MTA) is considered as a biomarker for Alzheimer's disease (AD) [ 1 - 6] and visual MTA ratings are available for clinical use [ 7 ]. There is debate as to what cut-off scores should be used in clinical practice to optimally differentiate AD from controls without dementia [ 8] or with other types of dementia [ 9, 10 ].
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MTA correlation with quantitative volumetric methods ranged from -0.20 (p< 0.05) to -0.68 (p < 0.001) depending on the quantitative method used. Both MTA and FreeSurfer are able to distinguish dementia subgroups from CH. Suggested age-dependent MTA thresholds are 1 for the age group below 75 years and 1.5 for the age group 75 years and older.